Hot Ham and Cheese Biscuit Sandwiches

Name: Hot Ham and Cheese Biscuit Sandwiches
Prep time: 10 min
Total time: 45 min
Yield: 8
Ingredients: 1 can (16.3 oz) refrigerated Pillsbury™ Grands!™ Southern Homestyle Buttermilk Biscuits (8 Count); 16 thin slices deli honey ham; 8 slices Swiss cheese; 1/2 cup butter, melted; 1 1/2 tablespoons grainy Dijon mustard; 1 tablespoon poppy seed; 1 1/2 teaspoons soy sauce

Prep time:10 min
Total time:45 min
Ingredients:7
Servings:8
Calories per serving:430

By Created by Joanna(Opens in a new tab)Updated 02/27/2026

Hot Ham and Cheese Biscuit Sandwiches

Prep time:10 min
Total time:45 min
Ingredients:7
Servings:8
Calories per serving:430

Taking just 10 minutes of hands-on prep time, this easy recipe for hot ham and cheese biscuit sandwiches takes your favorite deli staples and turns them into the ultimate comfort food.

With layers of honey ham and melty Swiss cheese on golden, flaky Pillsbury™ Grands!™ Southern Homestyle Buttermilk Biscuits, topped with a savory, buttery sauce, this is a classic crowd-pleaser. Whether it’s brunch, a weeknight dinner, or game day, these hot ham and cheese biscuit sliders always hit the spot.

Recipe Ingredients

With just a few kitchen staples, you can pull together a crowd-pleasing dish that feels special but couldn’t be simpler.

Pillsbury™ Grands!™ Southern Homestyle Buttermilk Biscuits: Their fluffy, golden layers create the perfect base for these sandwiches and hold everything together. Plus, we love how they bring homemade baked goodness to this recipe.

Deli Honey Ham: The meat adds a savory, slightly sweet bite that balances nicely with the cheese. If you don’t have ham on hand, you can sub in any deli meat of your choice!

Swiss Cheese: This melts into gooey perfection, giving each sandwich creamy, tangy richness. If you don’t like Swiss, you can switch in any cheese you want.

Other Ingredients You’ll Need: Butter adds richness and helps the biscuits bake up golden-brown, tangy Dijon mustard cuts through that richness, and soy sauce brings an irresistibly savory note. A sprinkle of poppy seed adds crunch!

How to Make Hot Ham and Cheese Biscuit Sandwiches

Turning classic ham and cheese into warm, buttery sliders couldn’t be easier. Here’s a brief overview of the steps; read on for the full recipe!

1. Bake the Biscuits

Pre-bake Pillsbury™ Grands!™ Southern Homestyle Buttermilk Biscuits for just a bit less time than the package directions state—just enough so they’re fluffy and can be pulled apart. We found that baking about 12 minutes is the perfect amount.

2. Assemble the Sandwiches

Split the biscuits in half and layer them in a baking dish. Then, pile on folded slices of ham and Swiss cheese so every biscuit becomes its own little sandwich.

3. Top with Butter Sauce

Combine melted butter, Dijon mustard, poppy seed, and soy sauce to create a rich, buttery glaze to pour over the top. For the best flavor, the sauce should be mixed until it emulsifies, so the ingredients fully combine to create a smooth sauce.

4. Bake and Enjoy

A quick trip back to the oven finishes the dish, giving you golden-topped, melty, savory sandwiches that are just as perfect for game day parties as they are for weeknight dinners.

Storing and Reheating Hot Ham and Cheese Biscuit Sandwiches

Leftovers don’t last long with these hot ham and cheese biscuit sandwiches, but if you’re lucky enough to have some, they reheat easily for another round of melty, savory goodness.

Refrigerator

Store leftover sliders in an airtight container for up to 3 days.

Freezer

We wouldn’t recommend freezing these hot ham and cheese biscuit sandwiches as the texture of the biscuits will not hold up when thawed and reheated.

Reheating

Microwave each serving on a plate in 1-minute intervals on High, or put sandwiches on a baking sheet and heat in a 350°F oven for 10 minutes, until heated through.